Clinical Trials at Curative

Since the company's establishment in January 2020, Curative has been committed to innovation, discovery, and safety.
Studies are conducted by doctors and researchers to help answer important medical questions. Learn more about our current clinical trials below.
Diversity
Viral Variant Project

Longitudinal Study Investigating Immune Escape by SARS-CoV-2 Variant

The purpose of this study is to investigate the ability of pre-existing immunity by natural infection or vaccination to prevent infections by emerging SARS-CoV-2 variants. Certified phlebotomists collect blood and observe a self-collected shallow nasal sample during 4 at-home collections over the course of 98 days.

We are currently enrolling participants ages 18-50 in 3 of the 5 enrollment groups:

  1. Those who have never had COVID and recently received (or plan to receive) their first Moderna booster vaccine
  2. Those who have never had COVID and recently received (or plan to receive) their first Pfizer-BioNTech booster vaccine
  3. Those who recently tested positive for COVID and are unvaccinated

Participants are compensated for their time. Submit the form below for more information.

Cardiometabolic Study

Comparison of Digital Weight Loss Methods

The purpose of this study is to compare several approaches to weight loss and diabetes management so that Curative may select programs that will have the best results for future target commercial insurance health plan members.

Enrolled participants ages 18-75 with a BMI greater or equal to 25 are randomly assigned to one of four commercially available weight loss programs for a 12-month period. Participants are expected to actively participate in the program for 12 months to evaluate how well the program does at supporting weight loss. The programs are provided at no cost to the participants.

Participants visit one of three Curative Labs (San Dimas, California, Monrovia, CA, or Austin/Round Rock, Texas) for 6 health visits at: baseline (enrollment), 3-months, 6-months, 9-months, and 12-months with a final follow up at the 24-month mark. At each of the health visits, there will be a physical examination, a blood draw, and a questionnaire. 

Participants are compensated for their time.

LEARN MORE

To determine your eligibility and sign up for the study, click the button below.

SIGN UP

Long/ Short COVID-19 Study

Investigation of Biomarkers for Long COVID

The purpose of this study is to identify biomarkers in long COVID patients (symptoms >6 months) that differentiate them from individuals who have fully recovered from infection in order to establish diagnostic criteria for long COVID or post COVID syndrome. The 3 enrollment groups include those who have only been infected with COVID once and either had symptoms for 6 or more, those who only had symptoms for a month or less, or those who have never been infected with COVID.

Interested parties fill out a survey to determine eligibility and, if eligible, are contacted by study staff to complete enrollment. Certified phlebotomists collect blood and observe a self-collected shallow nasal as well as have participants self-collect urine at each of 4 at home collections (one baseline collection and 3 more collections every 3 months). Participants will also participate in survey check-ins on a monthly basis and report any changes in symptoms or new COVID infections.

Participants are compensated for their time.

Enrollment in this study is temporarily paused, however if interested please fill out the appropriate form and study staff will contact you, if eligible, once enrollment resumes:

If you have never had COVID-19

If you have been infected once

14-Day Post COVID Survey

The purpose of this survey is to collect data to learn more about the public's access to medical professionals post COVID-19 diagnosis and the treatment options that they are aware of and pursue. Participants are selected to complete a COVID-19 treatment survey based on one of their previous COVID-19 test results with Curative.

Survey responses are currently being accepted. There is no compensation offered for the survey.

If you have tested positive for COVID-19 in the last 14 days, and are interested in completing a short questionnaire, click the button below.

COMPLETE QUESTIONNAIRE

 

Post-Vaccination Antibody Study

Characterizing Antibody Response to Different COVID-19 Vaccines

The purpose of this study is to investigate the ability of COVID-19 vaccines to elicit the production of SARS-CoV-2 IgG antibodies in the upper respiratory tract, such as in oral and nasal mucosal fluid, and to better understand these antibodies over time. Interested and eligible individuals at Curative vaccination sites are enrolled on the day of their first dose of the Moderna, Pfizer-BioNTech, or Johnson and Johnson COVID-19 vaccine.

At enrollment, participants are taught to self-collect oral and nasal samples for antibody and PCR testing. Baseline collections are completed onsite at which time participants are given supplies to self-collect oral and nasal samples on days 5, 10, 15, and 20 after each vaccine dose. Once these time points are completed, participants collect oral and nasal samples monthly for up to a year.

Participants have the option to participate in a follow up booster blood collection study. A baseline collection is obtained prior to receiving the booster vaccine and then every 5 days following vaccination on a schedule identical to initial enrollment (day 5, 10, 15, and 20). At each of these home collections a blood draw, self-collected nasal and oral swabs are obtained by certified phlebotomists. After the initial 20 days post vaccination participants resume mailing in self-collected oral and nasal collections on a monthly basis for up to a year.

Enrollment in this study has concluded.

Emerging Variants Study

Investigating Emerging SARS-CoV-2 Variants

The purpose of this study is to monitor emerging SARS-CoV-2 variants. Participants provide self-collected oral and nasal samples during a one-time home visit with a certified phlebotomist. The specimens are sequenced to determine genomic characteristics and lineage. For qualified participants, there will also be an optional follow-up blood collection at home by a trained phlebotomist.

Enrollment in this study has concluded.

Partnered Studies

Curative proudly partners with universities, laboratories, medical device and health care companies to facilitate innovative research. If interested in partnering with Curative on a study, please fill out the form below.

University of Southern California (USC) Child Infectiousness Study

Understanding Infectiousness of SARS-CoV-2 in Children

The purpose of this study is to evaluate the extent and duration of infectiousness of SARS-CoV-2 infection in school age children who are both vaccinated (breakthrough cases) and unvaccinated and to evaluate how infectiousness is associated with variant of infection, age, symptoms, days since symptom onset, days since exposure, and days since positive PCR test result.

Participants ages 7-18 who recently tested positive self-collect a shallow nasal swab during 5 separate home collections within 10 days of their initial date of infection and complete 2 questionnaires (at baseline collection and at completion).

Participants are compensated for their time. If interested in partnering with Curative on this study, please fill out the form below.